Dr. Joloba has developed skills in conducting clinical microbiology, laboratory-based research and training as well as building laboratory capacity in Uganda and other countries. Initially he graduated as a physician at Makerere Medical School in 1994 and later as a clinical microbiologist at Case Western Reserve University (graduated in May 1996, MS Degree) after which he returned to Uganda and took a faculty position at Makerere university Department of Medical Microbiology.
He also helped to establish a TB laboratory for the Tuberculosis Research Units (TBRU) and became its technical director and later a scientific director site (1996 - 1999). During that time a number of laboratory based studies were conducted and published many with Dr. Joloba as the first author. These involved research on Early Bactericidal Activity (EBA), quantitative bacillary response to therapy and evaluation of new markers to therapy. In addition, the TB laboratory was successfully involved in collection, processing, storage and shipment of samples for the World Health Organization Biorepository for TB diagnostic samples in 1998 -1999. The samples handled included sputum, saliva, serum and urine.
In 2000 - 2003, Dr. Joloba undertook a Ph.D course at Case Western in Microbiology and Molecular Biology. After his return Dr. Joloba, with support of NIH and Gates Foundation, he established a Molecular Biology, immunology and mycobacteriology laboratories at the University. He became the Director of the National TB Reference laboratory now a supranational laboratory. All the laboratories have successfully established capacity to receive, process, store and ship various samples. Over 50,000 samples are either received or shipped from these laboratories annually.
Dr. Joloba is a TB laboratory consultant for World Health Organization. He is a monitor for clinical laboratories and a trainer of Good Clinical Laboratory Practice. Using his previous experience in biobanks, he has since been a key monitor in selection of sites and handling of samples for a successful WHO TB biobank in Kenya and South Africa in 2005. Dr. Joloba has won over 8 grants and published over 70 peer reviewed papers, he is a reviewer for 6 journals and been an author of a book chapter.
Dr. Joloba has developed skills in setting up standard laboratories, running and monitoring biobanks, initiating and participating in successful North to South and South to South collaborations, conducting laboratory-based research as well as training of graduate students. Dr. Joloba has trained 33 Masters and 14 Doctoral students. Dr. Joloba is the Program Coordinator of the World Bank East African Public Health Laboratory Network - EAPHLN - as is in charge of Laboratory Accreditation and Networking in East Africa. This project is worth US$100 million.
Prof. Nelson K. Sewankambo, a Professor of Medicine is the former Principal (Head) of Makerere University College of Health Sciences a position he took up after serving as Dean of Makerere University Medical School for 11 years. He has devoted his last 13 years of professional life to the advancement of medical education, research and capacity development.
As Dean he was responsible for change from a teacher centered lecture based medical curriculum to student centered education grounded in Problem Based Learning and Community Based Education and Service. Some other innovations have included introduction of multi-disciplinary student education in teams, increasing the use of information technology in health professional education and joint doctoral degree programs between Makerere and Karolinska Institute (Sweden) and Bergen University (Norway).
He has led teams of academicians composed of experts in Europe, North America and Africa to develop and manage a very successful model for strengthening a medical school in the developing world - the Infectious Diseases Institute at Makerere and there are now plans to replicate this in Nigeria. Dr. Sewankambo also initiated a successful research capacity building consortium involving seven African institutions (4 universities and 3 research institutes) and two universities in the UK.
He is providing leadership for and Africa wide initiative for Strengthening Research Capacity in Africa (ISHReCA). He was founder Principal Investigator in Uganda for the internationally re-known Rakai Health Sciences Program (formerly Rakai Project) where he continues to be an active researcher/investigator and has contributed the large volume of scientific publications in peer reviewed journals together with providing mentorship and development of many Ugandan junior and mid-level researchers.
Prof. Sewankambo has been elected to the IOM one of the highest honors in the fields of health and medicine, which recognizes individuals who have demonstrated outstanding professional achievement and commitment to service. He has made major contributions to the advancement of the medical sciences, health care, and public health.
Dr. Misaki is a medical doctor (MBChB, 2004) with postgraduate (MSc) training in immunology and clinical microbiology. He holds tenure as lecturer of genetics/genomics & immunology at Makerere University, Kampala, Uganda in the Depts. of pathology and medical microbiology. My research interests center on the immunology of HIV and other viral vaccines, as well as emerging genetic/genomic approaches for the cure of all persistent viral infections.
He is a member of the steering committee of the young and early careers investigators (YECI) of the Global HIV Vaccine Enterprise. He is also non-executive member of the IAS "Towards an HIV Cure" group. He has worked on the R-M system model for an HIV cure since 1999, and the proposed zinc finger nuclease (ZFN) gene-therapies for HIV and other viruses are a direct result of these efforts.
More recently, He is collaborating with Prof. Keith Jerome on proviral DNA target mutagenesis as a strategy for HIV cure. He is an active member of the African Society for Human Genetics/Genomics, and Co-Chair of the Education Working Group of the H3Africa Consortium. He has biorepository management training from the ESBB/ISBER, experience with handling cell-lines through the NIH-AIDS Reagent Program and my current projects.
Dr. David research interestes are in understanding pathogen biology and host-pathogen interactions, generating knowledge that may translate into new medical interventions against leading diseases in Africa. Initially he trained as a veterinarian at Makerere University in Uganda, and joined pioneer-molecular laboratories to study parasite biology. Since 2006 he has served as a fulltime Lecturer at Makerere University.
Dr. David is also a scientific director and advisor, Department of Medical Microbiology, Makerere University. He has pioneered, coordinated and taught undergraduate and graduate degree programs and courses at Makerere University.
He undertook PhD studies during 2006 - 2012 for which he won a scholarship from a Fogarty-funded program that supported outstanding graduate students admitted to local universities. Following my PhD training capacity for basic/biomedical research has been established; PCRs, DNA cloning and construction of bacterial mutant strains are now among the many routine procedures performed. For additional skills I have trained in various state of the art research laboratories across borders; for instance, protein prenylationin Prof. Michael Gelb's laboratory at the University of Washington; bioinformatics in Dr. Jessica Kissinger's laboratory at the University of Georgia.
Currently he is embracing the power of bioinformatics to better understand pathogen biology and host-pathogen-environment interactions. For this he has completed 2 years of training at the University of Georgia where the use of bioinformatics to unravel host and pathogen genotypes influencing HIV-associated tuberculosis in Uganda was emphasized. In addition to bioinformatics skills, I also learned handling and archiving of human, animal and microbiological data and samples for future studies. I am a team-member of the H3Africa consortia serving on genome infrastructure and bioinformatics committees in the recently awarded Collaborative African Genomics Network.
He has served on the IBRH3AU executive committee which is overseeing activities of the skeleton staff during phase I; in the proposed phase II, he will continue serving on genomics, bioinformatics and molecular-related activities.
Dr. Samuel Kyobe is a medical doctor qualified from Makerere University. He is a former MEPI-MESAU scholar of Medical Microbiology at Makerere University College of Health Sciences (5R24TW008886 OGAC, NIH and HRSA, Sewankambo N. PI) mentored by of Prof. Moses Joloba. He Worked as a Resident Medical Officer at Rubaga Hospital Kampala for between 2009-2010. He later joined the Department of Microbiology as a junior staff, and later elected to manage the molecular biology laboratory tasked with the production of quality basic science research as cloning, gene knock out and site directed mutagenesis.
He possesses skills in performing molecular epidemiological studies for tuberculosis using techniques such as MIRU-VNTR, RFLP, and SNP genotyping. He has competencies in using molecular methodologies for pathogen detection and identification as well as genotypic drug resistance detection and treatment monitoring. He has special interest in the field of biobanking and has come to appreciate its role in the development of health interventions.
Dr. Kyobe has attended several international (ESBB) biobanking conferences where he has accrued exposure and knowledge on the currents international status of biobanking and biospecimen science. Dr. Kyobe is a member of the Steering Committee of the IARC (International Agency for Research and Cancer) initiated Low and Middle income countries Biobanking-Cohort Network (BCNet) aimed at developing biorepositories in low and middle income countries.
He has visited and conducted training at two International biorepositories in the USA that is East Coast-AIDS and Specimen Cancer Resource (EA-ASCR) Biorepository at George Washington University and the International Clinical Research Center (ICRC) Biorepository at University of Washington, on the application of ISBER best practices in biobanks. In the H3Africa consortium under the IBRH3AU he has pioneered the implementation of SPREC Coding for QA/QC management at biospecimen collection site. He has also spearheaded the innovation to develop the SPREC Code for complex biospecimen derivatives that compose the bulk of H3Africa collections.