The SPREC parameters are fairly embedded with the H3Africa harmonized SOPs, Each biospecimen will be assigned an eight-element-long code that corresponds to seven pre-analytical variables for fluids. For complex derivatives a five-element-long code was proposed. The SPREC is applied to primary samples (e.g., whole blood, urine, and solid tissue), their simple derivatives (e.g., after centrifugation of collection tubes or mechanical disruption of tissues) and complex derivatives (e.g. DNA, RNA and cell lines). Primary samples are defined as biospecimens directly collected from the donor. Simple derivatives are defined as the samples prepared through a simple laboratory manipulation without the addition of chemical substances by the laboratory technician and without cell disruption or cell selection as part of a multistep process.

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